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\u526f\u4f5c\u7528\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u304c\u3001\u30aa\u30ec\u30ad\u30b7\u30f3\u53d7\u5bb9\u4f53\u62ee\u6297\u85ac\u306f\u4ee5\u4e0b\u306e\u85ac\u5264\u3068\u306e\u4f75\u7528\u306f\u3067\u304d\u307e\u305b\u3093\u3002<\/p>\n\n\n\n

\u30fb\u30af\u30fc\u30d3\u30d3\u30c3\u30af<\/strong><\/p>\n\n\n\n

\u30a4\u30c8\u30e9\u30b3\u30ca\u30be\u30fc\u30eb\uff08\u30a4\u30c8\u30ea\u30be\u30fc\u30eb\uff09 \u30af\u30e9\u30ea\u30b9\u30ed\u30de\u30a4\u30b7\u30f3\uff08\u30af\u30e9\u30ea\u30b9\u3001\u30af\u30e9\u30ea\u30b7\u30c3\u30c9\uff09 \u30dc\u30ea\u30b3\u30ca\u30be\u30fc\u30eb\uff08\u30d6\u30a4\u30d5\u30a7\u30f3\u30c9\uff09 \u30dd\u30b5\u30b3\u30ca\u30be\u30fc\u30eb\uff08\u30ce\u30af\u30b5\u30d5\u30a3\u30eb\uff09 \u30ea\u30c8\u30ca\u30d3\u30eb\u542b\u6709\u88fd\u5264 \uff08\u30ab\u30ec\u30c8\u30e9\u3001\u30ce\u30fc\u30d3\u30a2\u3001 \u30d1\u30ad\u30ed\u30d3\u30c3\u30c9\uff09 \u30b3\u30d3\u30b7\u30b9\u30bf\u30c3\u30c8\u542b\u6709\u88fd\u5264 \uff08\u30b7\u30e0\u30c4\u30fc\u30b6\u3001\u30b2\u30f3\u30dc\u30a4 \u30e4\u3001\u30d7\u30ec\u30b8\u30b3\u30d3\u30c3\u30af\u30b9\uff09 \u30bb\u30ea\u30c1\u30cb\u30d6\uff08\u30b8\u30ab\u30c7\u30a3\u30a2\uff09 \u30a8\u30f3\u30b7\u30c8\u30ec\u30eb\u30d3\u30eb \u30d5\u30de\u30eb\u9178\uff08\u30be\u30b3\u30fc\u30d0\uff09<\/p>\n\n\n\n

\u30fb\u30dc\u30eb\u30ba\u30a3<\/strong><\/p>\n\n\n\n

\u30a4\u30c8\u30e9\u30b3\u30ca\u30be\u30fc\u30eb \u3000\uff08\u30a4\u30c8\u30ea\u30be\u30fc\u30eb\uff09 \u30dd\u30b5\u30b3\u30ca\u30be\u30fc\u30eb \u3000\uff08\u30ce\u30af\u30b5\u30d5\u30a3\u30eb\uff09 \u30dc\u30ea\u30b3\u30ca\u30be\u30fc\u30eb \u3000\uff08\u30d6\u30a4\u30d5\u30a7\u30f3\u30c9\uff09 \u30af\u30e9\u30ea\u30b9\u30ed\u30de\u30a4\u30b7\u30f3 \u3000\uff08\u30af\u30e9\u30ea\u30b9\uff09 \u3000\uff08\u30af\u30e9\u30ea\u30b7\u30c3\u30c9\uff09 \u30ea\u30c8\u30ca\u30d3\u30eb\u542b\u6709\u88fd\u5264 \u3000\uff08\u30ce\u30fc\u30d3\u30a2\uff09 \u3000\uff08\u30ab\u30ec\u30c8\u30e9\uff09 \u3000\uff08\u30d1\u30ad\u30ed\u30d3\u30c3\u30c9\uff09 \u30a8\u30f3\u30b7\u30c8\u30ec\u30eb\u30d3\u30eb\u3000\u30d5\u30de\u30eb\u9178 \u3000\uff08\u30be\u30b3\u30fc\u30d0\uff09 \u30b3\u30d3\u30b7\u30b9\u30bf\u30c3\u30c8\u542b\u6709\u88fd\u5264 \u3000\uff08\u30b2\u30f3\u30dc\u30a4\u30e4\uff09 \u3000\uff08\u30b7\u30e0\u30c4\u30fc\u30b6\uff09 \u3000\uff08\u30d7\u30ec\u30b8\u30b3\u30d3\u30c3\u30af\u30b9\uff09 \u30bb\u30ea\u30c1\u30cb\u30d6 \u3000\uff08\u30b8\u30ab\u30c7\u30a3\u30a2\uff09<\/p>\n\n\n\n

\u30fb\u30d9\u30eb\u30bd\u30e0\u30e9<\/strong><\/p>\n\n\n\n

\u30a4\u30c8\u30e9\u30b3\u30ca\u30be\u30fc\u30eb \uff08\u30a4\u30c8\u30ea\u30be\u30fc\u30eb\uff09 \u30dd\u30b5\u30b3\u30ca\u30be\u30fc\u30eb \uff08\u30ce\u30af\u30b5\u30d5\u30a3\u30eb\uff09 \u30dc\u30ea\u30b3\u30ca\u30be\u30fc\u30eb \uff08\u30d6\u30a4\u30d5\u30a7\u30f3\u30c9\uff09 \u30af\u30e9\u30ea\u30b9\u30ed\u30de\u30a4\u30b7\u30f3 \uff08\u30af\u30e9\u30ea\u30b7\u30c3\u30c9\uff09 \u30dc\u30ce\u30d7\u30e9\u30b6\u30f3\u30fb\u30a2\u30e2 \u30ad\u30b7\u30b7\u30ea\u30f3\u30fb\u30af\u30e9\u30ea \u30b9\u30ed\u30de\u30a4\u30b7\u30f3 \uff08\u30dc\u30ce\u30b5\u30c3\u30d7\uff09 \u30e9\u30d9\u30d7\u30e9\u30be\u30fc\u30eb\u30fb\u30a2 \u30e2\u30ad\u30b7\u30b7\u30ea\u30f3\u30fb\u30af\u30e9 \u30ea\u30b9\u30ed\u30de\u30a4\u30b7\u30f3 \uff08\u30e9\u30d9\u30ad\u30e5\u30a2\uff09 \u30ea\u30c8\u30ca\u30d3\u30eb \uff08\u30ce\u30fc\u30d3\u30a2\uff09 \u30cb\u30eb\u30de\u30c8\u30ec\u30eb\u30d3\u30eb\u30fb \u30ea\u30c8\u30ca\u30d3\u30eb \uff08\u30d1\u30ad\u30ed\u30d3\u30c3\u30c9\uff09 \u30a8\u30f3\u30b7\u30c8\u30ec\u30eb\u30d3\u30eb \uff08\u30be\u30b3\u30fc\u30d0\uff09 \u30bb\u30ea\u30c1\u30cb\u30d6 \uff08\u30b8\u30ab\u30c7\u30a3\u30a2\uff09<\/p>\n\n\n\n

\uff0a\u30c7\u30a8\u30d3\u30b4\u306f\u4f75\u7528\u7981\u5fcc\u85ac\u306f\u3042\u308a\u307e\u305b\u3093\uff08\u4f75\u7528\u6ce8\u610f\u85ac\u306f\u3042\u308a\u307e\u3059\uff09\u3002<\/p>\n\n\n\n

\n\n\n\n

\u2605\u30dc\u30eb\u30ba\u30a3\u3068\u30af\u30fc\u30d3\u30d3\u30c3\u30af\u306e\u7279\u5fb4\u2605<\/strong><\/p>\n\n\n\n

\uff0a\u30af\u30fc\u30d3\u30d3\u30c3\u30af\uff08\u30c0\u30ea\u30c9\u30ec\u30ad\u30b5\u30f3\u30c8\u5869\u9178\u5869\uff09<\/strong><\/p>\n\n\n\n

\u4e09\u89d2\u5f62\u306e\u304a\u306b\u304e\u308a\u307f\u305f\u3044\u306a\u5f62\u306e\u9320\u5264\u3067\u3059\u3002<\/p>\n\n\n\n

\u30af\u30fc\u30d3\u30d3\u30c3\u30af\u306f\u6d88\u5931\u534a\u6e1b\u671f\uff08T1\/2\uff1a\u85ac\u7269\u306e\u8840\u4e2d\u6fc3\u5ea6\u304c\u6700\u3082\u9ad8\u304f\u306a\u3063\u3066\u304b\u3089\u534a\u6e1b\u3059\u308b\u306e\u306b\u8981\u3059\u308b\u6642\u9593\uff09\u304c\u4e00\u756a\u77ed\u3044\u3053\u3068\u304c\u7279\u5fb4\u3067\u3001\uff15\uff10\u338e\u3067\u306f\uff18\uff0e\uff18\uff17\u6642\u9593\u3067\u3059\u3002\u307e\u305f\u3001\u6700\u9ad8\u8840\u6f3f\u4e2d\u6fc3\u5ea6\u5230\u9054\u6642\u9593(Tmax\uff1a\u85ac\u7269\u3092\u670d\u7528\u3057\u305f\u5f8c\u3001\u8840\u4e2d\u6fc3\u5ea6\u304c\u6700\u3082\u9ad8\u304f\u306a\u308b\u6642\u9593\uff09\u306f\uff12\u6642\u9593\u3067\u3059\u3002<\/p>\n\n\n\n

\u30dc\u30eb\u30ba\u30a3\u307b\u3069\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u304c\u3001\u30d9\u30eb\u30bd\u30e0\u30e9\u3001\u30c7\u30a8\u30d3\u30b4\u3068\u6bd4\u8f03\u3059\u308b\u3068\u6d88\u5931\u534a\u6e1b\u671f\u306f\u77ed\u3044\u305f\u3081\u3001\u30dc\u30eb\u30ba\u30a3\u540c\u69d8\u306b\u7761\u7720\u5c0e\u5165\u5264\u7684\u306a\u7acb\u3061\u4f4d\u7f6e\u306e\u85ac\u5264\u3067\u3059\u3002<\/p>\n\n\n\n

\u30af\u30fc\u30d3\u30d3\u30c3\u30af\u306f\uff15\uff10\u338e\u304c\u958b\u59cb\u91cf\u3067\u3001\u305d\u308c\u4ee5\u4e0a\u5897\u91cf\u3059\u308b\u3053\u3068\u306f\u3067\u304d\u307e\u305b\u3093\u3002\u85ac\u304c\u52b9\u304d\u3084\u3059\u3044\u65b9\u3084\u3001\u3054\u9ad8\u9f62\u306e\u65b9\u306e\u5834\u5408\u3001\uff12\uff15\u338e\u304b\u3089\u958b\u59cb\u3059\u308b\u3053\u3068\u3082\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n

\uff0a\u30dc\u30eb\u30ba\u30a3\uff08\u30dc\u30eb\u30ce\u30ec\u30ad\u30b5\u30f3\u30c8\u6c34\u548c\u7269\uff09<\/strong><\/p>\n\n\n\n

\u30dc\u30eb\u30ba\u30a3\u306f\u6d88\u5931\u534a\u6e1b\u671f\u304c\uff08T1\/2\uff1a\u85ac\u7269\u306e\u8840\u4e2d\u6fc3\u5ea6\u304c\u6700\u3082\u9ad8\u304f\u306a\u3063\u3066\u304b\u3089\u534a\u6e1b\u3059\u308b\u306e\u306b\u8981\u3059\u308b\u6642\u9593\uff09\u304c\u4e00\u756a\u77ed\u3044\u3053\u3068\u304c\u7279\u5fb4\u3067\u3059\u3002<\/p>\n\n\n\n

\u30dc\u30eb\u30ba\u30a3\uff11\uff10\u338e\u3067\u306f\uff12\uff0e\uff11\uff13\uff08\u00b1\uff10\uff0e\uff11\uff18\uff15\uff09\u6642\u9593\u3067\u3059\u3002\u307e\u305f\u3001\u6700\u9ad8\u8840\u6f3f\u4e2d\u6fc3\u5ea6\u5230\u9054\u6642\u9593(Tmax\uff1a\u85ac\u7269\u3092\u670d\u7528\u3057\u305f\u5f8c\u3001\u8840\u4e2d\u6fc3\u5ea6\u304c\u6700\u3082\u9ad8\u304f\u306a\u308b\u6642\u9593\uff09\u306f\uff10\uff0e\uff15\u6642\u9593\u3068\u306a\u308a\u307e\u3059\u3001<\/p>\n\n\n\n

\u3053\u306e\u6570\u5024\u306e\u7d50\u679c\u304b\u3089\u306f\u3001\u7fcc\u65e5\u306b\u7720\u308a\u304c\u6b8b\u308a\u306b\u304f\u304f\u3001\u307e\u305f\u901f\u3084\u304b\u306a\u5165\u7720\u4fc3\u9032\u52b9\u679c\u304c\u3042\u308b\u3068\u63a8\u6e2c\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n

\u30aa\u30ec\u30ad\u30b7\u30f3\u53d7\u5bb9\u4f53\u62ee\u6297\u85ac\u306e\u4e2d\u3067\u306f\u6d88\u5931\u534a\u6e1b\u671f\u304c\u4e00\u756a\u77ed\u3044\u85ac\u5264\u3068\u306a\u308a\u307e\u3059\u3002\u7761\u7720\u5c0e\u5165\u5264\u3068\u3057\u3066\u4f7f\u7528\u3059\u308b\u3053\u3068\u304c\u4e3b\u3067\u3059\u3002<\/p>\n\n\n\n

5\u338e\u304c\u958b\u59cb\u91cf\u3067\u3001\uff11\uff10\u338e\u307e\u3067\u6295\u4e0e\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002\u30dc\u30eb\u30ba\u30a3\u3082\u304a\u85ac\u304c\u52b9\u304d\u3084\u3059\u3044\u65b9\u3001\u3054\u9ad8\u9f62\u306e\u65b9\u306e\u5834\u5408\u306f\u3001\uff12\uff0e\uff15\u338e\u304b\u3089\u958b\u59cb\u3059\u308b\u3053\u3068\u3082\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n

\u30dc\u30eb\u30ba\u30a3\u306e\u30c7\u30e1\u30ea\u30c3\u30c8\u306f\u3001\u85ac\u52b9\u3084\u526f\u4f5c\u7528\u306b\u95a2\u3059\u308b\u3053\u3068\u3067\u306f\u306a\u3044\u3067\u3059\u304c\u3001\uff12\uff10\uff12\uff15\u5e74\uff11\uff11\u6708\u306b\u65b0\u898f\u306b\u767a\u58f2\u3055\u308c\u305f\u85ac\u5264\u306e\u305f\u3081\u3001\uff11\u5e74\u9593\u306f\uff11\uff14\u65e5\u9593\u3057\u304b\u51e6\u65b9\u304c\u51fa\u6765\u306a\u3044\u3053\u3068\u3067\u3059\uff08\u3069\u306e\u3088\u3046\u306a\u85ac\u5264\u3067\u3082\u767a\u58f2\u3055\u308c\u3001\uff11\u5e74\u9593\u306f\uff11\uff14\u65e5\u9593\u3057\u304b\u51e6\u65b9\u304c\u51fa\u6765\u306a\u3044\u6c7a\u307e\u308a\u304c\u3042\u308a\u307e\u3059\uff09\u3002<\/p>\n\n\n\n

\n\n\n\n
\u4e00\u822c\u540d<\/td>\u5546\u54c1\u540d<\/td>\u898f\u683c<\/td>T1\/2<\/td>Tmax<\/td><\/tr>
\u30c0\u30ea\u30c9\u30ec\u30ad\u30b5\u30f3\u30c8<\/td>\u30af\u30fc\u30d3\u30d3\u30c3\u30af<\/td>25\u338e\u30fb50\u338e<\/td>8.87\u6642\u9593 *50\u338e<\/td>2\u6642\u9593<\/td><\/tr>
\u30dc\u30eb\u30ce\u30ec\u30ad\u30b5\u30f3\u30c8<\/td>\u30dc\u30eb\u30ba\u30a3<\/td>2.5\u338e\u30fb5\u338e\u30fb10\u338e<\/td>2.13\u6642\u9593(\u00b10.185)*10mg<\/td>0.5\u6642\u9593<\/td><\/tr>
\u30ec\u30f3\u30dc\u30ec\u30ad\u30b5\u30f3\u30c8<\/td>\u30c7\u30a8\u30d3\u30b4<\/td>2.5\u338e\u30fb5\u338e\u30fb10\u338e<\/td>47.4\u6642\u9593<\/td>1.55\u6642\u9593<\/td><\/tr>
\u30b9\u30dc\u30ec\u30ad\u30b5\u30f3\u30c8<\/td>\u30d9\u30eb\u30bd\u30e0\u30e9<\/td>10\u338e\u30fb15\u338e\u30fb20\u338e<\/td>10\u6642\u9593<\/td>1.5\u6642\u9593<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n
\n\n\n\n

\u2605\u307e\u3068\u3081\uff0b\u03b1\u2605<\/strong><\/p>\n\n\n\n

\u30aa\u30ec\u30ad\u30b7\u30f3\u53d7\u5bb9\u4f53\u62ee\u6297\u85ac\u306e\uff12\u5264\u3092\u4e2d\u5fc3\u306b\uff08\u30dc\u30eb\u30ba\u30a3\u3001\u30af\u30fc\u30d3\u30d3\u30c3\u30af\uff09\u306b\u3064\u3044\u3066\u8aac\u660e\u3092\u3057\u307e\u3057\u305f\u3002<\/p>\n\n\n\n

\u30aa\u30ec\u30ad\u30b7\u30f3\u53d7\u5bb9\u4f53\u62ee\u6297\u85ac\u306e\u6301\u7d9a\u6642\u9593\u306f\u77ed\u3044\u65b9\u304b\u3089\u9806\u306b\u30dc\u30eb\u30ba\u30a3\uff1e\u30af\u30fc\u30d3\u30d3\u30c3\u30af\uff1e\u30d9\u30eb\u30bd\u30e0\u30e9\uff1e\u30c7\u30a8\u30d3\u30b4\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n

\u30d9\u30eb\u30bd\u30e0\u30e9\u3084\u30c7\u30a8\u30d3\u30b4\u3082\u826f\u3044\u304a\u85ac\u3067\u3059\u304c\u3001\u52b9\u679c\u6642\u9593\u304c\u9577\u3059\u304e\u308b\u305f\u3081\u3001\u4f7f\u3044\u306b\u304f\u3044\u6642\u3082\u3042\u308a\u307e\u3057\u305f\u3002\u30dc\u30eb\u30ba\u30a3\u3084\u30af\u30fc\u30d3\u30d3\u30c3\u30af\u306e\uff12\u5264\u304c\u767b\u5834\u3057\u3066\u304f\u308c\u305f\u304a\u304b\u3052\u3067\u3001\u4ee5\u524d\u3088\u308a\u3082\u30aa\u30ec\u30ad\u30b7\u30f3\u53d7\u5bb9\u4f53\u62ee\u6297\u85ac\u306e\u9078\u629e\u80a2\u304c\u5897\u3048\u3001\u4e0d\u7720\u6cbb\u7642\u306e\u5e45\u304c\u5e83\u304c\u308a\u3001\u52a9\u304b\u3063\u3066\u304a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n

\u305f\u3060\u3001\u7720\u308c\u306a\u3044\u5834\u5408\u306f\u7761\u7720\u85ac\u306b\u983c\u308a\u904e\u304e\u305a\u3001\u53ef\u80fd\u3067\u3042\u308c\u3070\u7761\u7720\u65e5\u8a8c\u3092\u8a18\u8f09\u3059\u308b\u306a\u3069\u3001\u81ea\u5206\u306e\u7761\u7720\u72b6\u614b\u3092\u8a18\u9332\u3059\u308b\u3088\u3046\u306b\u3057\u3066\u307f\u307e\u3057\u3087\u3046\u3002\u7761\u7720\u30a2\u30d7\u30ea\u3092\u6d3b\u7528\u3059\u308b\u3053\u3068\u3082\u6709\u52b9\u3067\u3059\u3002<\/p>\n\n\n\n

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\u8cc7\u6599 | \u65e5\u672c\u3046\u3064\u75c5\u5b66\u4f1a Japanese Society of Mood Disorders<\/a><\/p>\n\n\n\n

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\n\n\n\n

\u53c2\u8003\u6587\u732e<\/strong><\/p>\n\n\n\n

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\u30fb\u6587\u732e\u3000\u7761\u7720\u969c\u5bb3\u306e\u5bfe\u5fdc\u3068\u6cbb\u7642\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u3000\u7b2c3\u7248\u30002019\u5e74\u3000\u3058\u307b\u3046<\/p>\n\n\n\n

\u30fb\u65e5\u672c\u3046\u3064\u75c5\u5b66\u4f1a\u30db\u30fc\u30e0\u30da\u30fc\u30b8\u3000\u65e5\u672c\u3046\u3064\u75c5\u5b66\u4f1a Japanese Society of Mood Disorders<\/a><\/p>\n\n\n\n

\u30fb\u7761\u7720\u85ac\u306e\u9069\u6b63\u4f7f\u7528\u3000\u30002014\u5e74\u3000\u3058\u307b\u3046<\/p>\n\n\n\n

\u30fb\u300c\u85ac\u304c\u307f\u3048\u308b\u3000vol.1 \u7b2c2\u7248\u300d\u3000\u30e1\u30c7\u30a3\u30c3\u30af\u30e1\u30c7\u30a3\u30a2<\/p>\n\n\n\n

\u30fbThe orexin story and orexin receptor antagonists for the treatment of insomnia<\/p>\n\n\n\n

\u3000Journal of sleep research\uff082023\/12\uff09<\/p>\n\n\n\n

\u30fbClinical pharmacology, efficacy, and safety of orexin receptor antagonists for the treatment of insomnia disorders<\/a><\/p>\n\n\n\n

Expert opinion on drug metabolism & toxicology\uff082020\/11\uff09<\/p>\n\n\n\n

\u30fbComparative efficacy and safety of daridorexant, lemborexant, and suvorexant for insomnia: a systematic review and network meta-analysis<\/a><\/p>\n\n\n\n

Translational psychiatry\uff082025\/06\/24\uff09<\/p>\n\n\n\n

\u30fbCurrent and novel dual orexin receptor antagonists for the treatment of insomnia: the emergence of vornorexant<\/a><\/p>\n\n\n\n

The international journal of neuropsychopharmacology\uff082025\/12\/01\uff09<\/p>\n\n\n\n

\u30fbDual orexin receptor antagonists in insomnia: Toward a new therapeutic paradigm<\/a><\/p>\n\n\n\n

Pharmacology, biochemistry, and behavior\uff082026\/01\uff09<\/p>\n\n\n\n

\n\n\n\n

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Instagram\u3092\u3084\u3063\u3066\u3044\u307e\u3059\u3002\u304a\u6642\u9593\u3042\u308a\u307e\u3057\u305f\u3089\u3054\u89a7\u304f\u3060\u3055\u3044\u3002<\/strong><\/p>\n\n\n\n

https:\/\/www.instagram.com\/mitaka_kokoro_egao\/<\/a><\/p>\n\n\n\n

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